- R R
Ryan ReynoldsWade Wilson / Deadpool / Nicepool
- H J
Hugh JackmanLogan / Wolverine
- E C
Emma CorrinCassandra Nova
- M M
Matthew MacfadyenMr. Paradox
- D K
Dafne KeenLaura / X-23
- J F
Jon FavreauHappy Hogan
- M B
Morena BaccarinVanessa
- R D
Rob DelaneyPeter
- L U
Leslie UggamsBlind Al
- J G
Jennifer GarnerElektra
- W S
Wesley SnipesBlade
- C T
Channing TatumGambit
- C E
Chris EvansJohnny Storm
- H C
Henry CavillThe Cavillrine
- W M
Wunmi MosakuB-15
- A S
Aaron StanfordPyro
- T M
Tyler ManeSabretooth
- K S
Karan SoniDopinder
- B H
Brianna HildebrandNegasonic Teenage Warhead
- S K
Shioli KutsunaYukio
- S K
Stefan KapičićColossus (voice)
- R R
Randal ReederBuck
- L T
Lewis TanShatterstar
- N P
Nick PauleyDancepool
- S H
Sonita HenryMrs. Chipman
- R M
Ryan McKenMr. Chipman
- N P
Nanak PhloraElliot Chipman
- A A
Aydin AhmedKevin Chipman
- L M
Leemore Marrett Jr.Minuteman Leader
- J D
James DrydenTVA Tech
- O P
Ollie PalmerBar Patron
- G H
Greg HemphillSeedy Bartender
- A W
Aaron W ReedJuggernaut
- M W
Mike WatersBlob
- R M
Rob MacTVA Soldier
- J R
James ReynoldsScreaming Mutant (voice)
- E K
Ed KearOutpost Tech
- P G
Paul G. RaymondTVA Office Agent
- B L
Blake LivelyLadypool (voice)
- I R
Inez ReynoldsKidpool (voice)
- N F
Nathan FillionHeadpool (voice)
- M M
Matthew McConaugheyCowboypool (voice)
- O R
OIin ReynoldsBabypool (voice)
- P M
Paul MullinWelshpool
- A K
Alex KyshkovychCanadapool
- B C
Billy ClementsRussian (uncredited)
- D M
Daniel Medina RamosToad (uncredited)
- J L
Jade LyeLady Deathstrike (uncredited)
- N C
Nilly CetinQuill (uncredited)
- E G
Eduardo Gago MuñozAzazel (uncredited)
- C K
Chloe KibbleCallisto (uncredited)
- C R
Curtis Rowland SmallBullseye (uncredited)
- A H
Ayesha HussainPsylocke (uncredited)
- J W
Jessica WalkerArclight (uncredited)
- H H
Harry HollandHaroldpool (uncredited)
- K F
Kevin FortinZenpool (uncredited)
- L B
Luke BennettComic-Accurate Wolverine Body Double (uncredited)
- A N
Anneka NeedhamTVA Agent (uncredited)
- G M
George MontagueJuggernaut Double
