- M M
Matthew McConaugheyCooper
- A H
Anne HathawayBrand
- M C
Michael CaineProfessor Brand
- J C
Jessica ChastainMurph
- C A
Casey AffleckTom
- W B
Wes BentleyDoyle
- T G
Topher GraceGetty
- M F
Mackenzie FoyMurph (10 Yrs.)
- E B
Ellen BurstynMurph (older)
- J L
John LithgowDonald
- B I
Bill IrwinTARS (voice)
- D G
David GyasiRomilly
- T C
Timothée ChalametTom (15 Yrs.)
- M D
Matt DamonMann
- J S
Josh StewartCASE (voice)
- L C
Leah CairnsLois
- L D
Liam DickinsonCoop
- F X
Francis X. McCarthyBoots
- W D
William DevaneWilliams
- A B
Andrew BorbaSmith
- E G
Elyes GabelAdministrator
- D O
David OyelowoSchool Principal
- C W
Collette WolfeMs. Hanley
- J H
Jeff HephnerDoctor
- R F
Russ FegaCrew Chief
- L G
Lena GeorgasNurse Practitioner
- B S
Brooke SmithNurse
- F N
Flora NolanGirl on Truck
- G F
Griffen FraserBoy on Truck
- K V
Kristian Van der HeydenScientist (uncredited)
- W P
William Patrick BrownNASA employee (uncredited)
- B H
Benjamin HardyNASA Scientist (uncredited)
- J O
Joseph OliveiraAstronaut (uncredited)
- A M
Alexander Michael HelisekConstruction boss (uncredited)
- R N
Rory NolanLittle Boy in the hospital (uncredited)
